Cultivated lamb is an early-stage cell-ag target. Systems-level data for Ovis aries is beginning to accumulate — most notably a multi-tissue atlas of genetic regulatory effects within the FarmGTEx family. Dedicated cultivated-lamb cell datasets remain sparse, but a cluster of conventional ovine meat-quality proteomics and metabolomics — catalogued below — offers reference substrate for the sensory- and quality-prediction problems cultivated lamb will share, and the page will grow as the field’s data accumulates.
Sheep sub-portal of the FarmGTEx consortium, providing multi-tissue regulatory-effects maps across sheep (Ovis aries) tissues — extending the FarmGTEx pattern from cattle, pig, and chicken into the small-ruminant lineage and a regulatory-genomics substrate for cultivated-lamb cell-line characterisation. Companion to Papers.md ref #138 (Gong et al. 2025, bioRxiv). Full entry in Databases.md / Livestock Multi-Tissue Atlases.
Ahead of dedicated cultivated-lamb cell datasets, a cluster of conventional ovine meat-quality omics studies — surfaced by walking the Encyclopedia of Meat Sciences omics reviews — provides reference substrate for the sensory- and quality-prediction problems cultivated lamb will share. A redox proteome of Tan mutton under low-temperature storage (Tao et al. 2021, LWT) catalogues 1,089 proteins carrying differentially changed oxidation sites; a roasting proteome of lamb longissimus thoracis et lumborum (Yu et al. 2016, Meat Science) tracks protein-profile and amino-acid-residue modifications with cooking; and a HILIC-MS metabolome of colour-stable versus colour-labile ovine longissimus (Subbaraj et al. 2016, Meat Science) maps the small-molecule basis of meat-colour stability. None of these three deposited to a repository — each study’s full data table lives in its supplementary materials. A more recent integrated proteomic and metabolomic comparison of climatically divergent breeds — heat-adapted Turpan Black versus cold-adapted Altay sheep (Yang et al. 2026, Foods) — links environmental adaptation to longissimus-dorsi meat-quality traits and, unlike the studies above, openly deposits its metabolome data at FigShare.
A chromatin-accessibility resource for Ovis aries arrives via a high-altitude hypoxia-acclimatization study that uses sheep as a plain-to-plateau transplant model and generates time-resolved bulk RNA-seq, ATAC-seq, and single-cell RNA-seq across multiple tissues (PRJNA1001505). For cultivated lamb it is an ovine open-chromatin and single-cell substrate — a regulatory-genomics reference for mapping the cis-regulatory landscape of cultivated-lamb cell lines, complementing the SheepGTEx regulatory-effects maps with chromatin-accessibility and single-cell resolution.
A curated snapshot — fetch the linked source (a paper’s supplementary materials or an SRA/BioProject accession) for the full data.
| Study | Paper | Data | Type | Tissue | Description | Size | Area of research |
|---|---|---|---|---|---|---|---|
| ATAC-Seq and scRNA-Seq for sheep hypoxia acclimatization | DOI | PRJNA1001505 | Bulk RNA-seq, ATAC-seq, scRNA-seq | Multiple tissues | Sheep high-altitude hypoxia-acclimatization multi-omics resource; time-resolved bulk RNA-seq, ATAC-seq, and single-cell RNA-seq from multiple tissues in a plain-to-plateau transplant model — an ovine chromatin-accessibility and single-cell deposit | — | Chromatin accessibility & regulatory genomics |
| Proteomics analysis to investigate the effect of oxidized protein on meat color and water holding capacity in Tan mutton under low temperature storage | DOI | supplementary | LC-MS/MS redox proteomics | Muscle | Tan mutton under −2/−4/−18 °C storage versus fresh control (Tao et al. 2021, LWT); full list of 1,089 proteins with differentially changed oxidation sites in Supplementary Table 1 — supplementary data, not a repository deposit | — | Redox proteome & meat quality |
| Proteomic investigation of protein profile changes and amino acid residue-level modification in cooked lamb longissimus thoracis et lumborum: the effect of roasting | DOI | supplementary | LC-MS/MS proteomics | Muscle (longissimus thoracis et lumborum) | Lamb LTL roasted 0/5/10 min (Yu et al. 2016, Meat Science); full per-run protein-identification reports and annotated MS/MS spectra of heat-modified peptides in Supplementary data 2–3 — supplementary data, not a repository deposit | — | Cooking proteomics |
| A hydrophilic interaction liquid chromatography-mass spectrometry (HILIC-MS) based metabolomics study on colour stability of ovine meat | DOI | supplementary | HILIC-MS metabolomics | Muscle (loin / longissimus) | Colour-stable versus colour-labile ovine loin (longissimus) under MAP/VAC packaging (Subbaraj et al. 2016, Meat Science); full detected-metabolite table (m/z, retention time, ionisation mode, confidence level, fold-change) in Supplementary Table S1 — supplementary data, not a repository deposit | — | Colour-stability metabolomics |
| Proteomic and metabolomic analysis reveals candidate biomarkers and meat quality differences in divergent climatically adapted sheep breeds | DOI | FigShare | LC-MS/MS proteomics + non-targeted metabolomics | Muscle (longissimus dorsi) | Heat-adapted Turpan Black (n=15) versus cold-adapted Altay (n=15) sheep (Yang et al. 2026, Foods); integrates phenotypic meat-quality evaluation with non-targeted metabolomics and proteomics of longissimus dorsi to map how environmental adaptation shapes ovine meat quality; metabolome data openly deposited at FigShare (the deposit’s title spans a third breed, Bayanbulak, beyond this paper’s Turpan Black vs Altay comparison); the paper states no deposit location for the proteomics data | — | Meat-quality proteome & metabolome |
| Comprehensive multi-tissue epigenome atlas in sheep: a resource for complex traits, domestication, and breeding | DOI | CRA019589 | ChIP-seq + ATAC-seq + RNA-seq | Nine major tissues (incl. longissimus dorsi, tail fat) | First multi-tissue epigenome atlas of sheep: 92 transcriptomic and epigenomic datasets across nine major tissues, cataloguing 753,723 nonredundant functional elements and their chromatin states; a regulatory-genomics reference for cultivated-lamb cell-line characterisation. Raw data at NGDC/GSA CRA019589 and CRA019576 | — | Multi-tissue regulatory genomics & epigenomics |
Curation source: These ovine meat-quality omics entries were curated by walking the cited references of the Encyclopedia of Meat Sciences (2024) reviews on proteomics (Gagaoua et al. 2024) and metabolomics (Kiyimba et al. 2024) in meat research. Contributions of further Ovis aries datasets relevant to cultivated meat are welcome — see CONTRIBUTING.md.
Databases.md. Foundational reference: Papers.md ref #138 (Gong et al. 2025, A multi-tissue atlas of genetic regulatory effects in sheep, bioRxiv).Software.md — especially useful where labelled species data is sparse.Linked external resources are independent of TUCCA and Tufts University and remain under their own licenses.